Creatine and Memantine: User Report- Three weeks. Surprising results and Sources

Creatine and Memantine: User Report- Three weeks. Surprising results and Sources

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As a long-time sufferer of intrusive cyclical-ruminating thoughts, and poor auditory and working memory, which has resulted in a history of poor academics and work station, no matter how hard”I try”.Academic history: Low GPA, bilingual with a tendency towards novelty-seeking, though I tried in earnest to be a good student and spent many hours studying and trying to master the materal asked of me.Successful work environments: Worked as an Assistant Manager in an Industrial Engineering capacity for a large logistics company… even though I really had no idea what I was doing. I learned the value of understanding systems and databases, which I applied in my research…( In my sources below).Diagnosed with BiP Type II, inattentive ADHD, allergies and Asthma…I think I’ve stumbled upon a combo that provides a number of noticeable improvements in my quality of thinking/life… They are as follows:

  • Not quick to fluster or get frustrated as before.

  • Auditory and visual working memory has improved to the point where I can recall phone numbers more easily than before and remember spoken instructions for longer periods of time. I can also have conversations without losing my train of thought.

  • Social interactions are not nearly as taxing or exhausting as they were before.

  • Much less “tip of the tongue” moments, or forgetting things when in a stressed state.

  • Significant decrease in allergy symptoms and asthma symptoms

  • Increased muscle tone and desire to drink water without urinating as much.

  • Do not feel the need to drink nearly as much coffee as I use and consume sugary things.

  • Improved social interactions with much less anxiety than before(significant).

  • My sense of smell has returned. Something I have not had in several years.

  • Not always craving sugary things (Mentioned twice because this is a biggie for me; though I am underweight)

  • Significantly improved quality of sleep.

  • Significantly improved social interactions and much less distractibility in noisy environments.

  • Desire to exercise and not tire as quickly as before.

  • Huperzine-A appears to last longer than before I started taking Memantine and Creatine…Hup-A lost it’s noticeable effects after less than an hour and now seems to last around 3 hours…Yes, I understand it has a 14 half life and must be used cautiously.

Amounts: 20MG Memantine before bed and 5G of Creatine in the morning.Time Taken for both: Three weeks.

Question: Any idea what other substances I can take to enhance the positive effects I am experiencing?

I hope the aforementioned observations are useful for someone who might have similar ailments as myself. Of course, check with your doctor first.Below, you’ll find my sources and summaries on the subject.

**Sources and theory(s) for why I picked Creatine and memantine( Below):**Note: Memantine: I became interested in substances working off of the NMDA pathway after I noticed I felt a reduction in ADHD symptoms when taking COQ10, L-Carnitine and Vitamin C; both of which work off of the NMDA pathway…At least that’s my understanding.Creatine Monohydratee: I became interested in this substance after learning of its importance in cell regeneration of the Mitochondria, specifically in a process related to ATP…Both implicated in certain instances of ADHD, Asthma and Allergies.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028535/“Title: Mitochondrial dysfunction increases allergic airway inflammation“” In conclusion, we have provided evidence that preexisting oxidative damage to mitochondria, prior the recruitment of inflammatory cells to the airways, intensified airway eosinophilia, increased mucin production, as well as enhanced bronchial hyperresponsiveness. Our findings further emphasize the role of mitochondria in the pathogenesis of allergic airway inflammation and asthma. Furthermore, they also imply that prevention or reduction of oxidative mitochondrial damage in the airways may have a beneficial role in therapy of these diseases”

http://vivo.med.cornell.edu/display/pubid65249129156Title: Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases

“This review discusses the contribution of mitochondria and bioenergetics to the progression of these neurodegenerative diseases and investigates the potential neuroprotective value of creatine supplementation in each of these neurological diseases. In summary, current literature suggests that exogenous creatine supplementation is most efficacious as a treatment paradigm in Huntington’s and Parkinson’s disease but appears to be less effective for ALS and Alzheimer’s disease.”

https://lpi.oregonstate.edu/mic/dietary-factors/coenzyme-Q10Title: Linus Pauling Institute: COQ10

  • “Oral high-dose coenzyme Q10 is usually effective to treat mitochondrial disorders that are caused by mutations in coenzyme Q10 biosynthetic genes. (More information)

  • The conversion of energy from carbohydrates and fats to ATP, the form of energy used by cells, requires the presence of coenzyme Q10 in the inner mitochondrial membrane. As part of the mitochondrial electron transport chain, coenzyme Q10 accepts electrons from reducing equivalents generated during fatty acid and glucose metabolism and then transfers them to electron acceptors. At the same time, coenzyme Q10 contributes to transfer protons (H+) from the mitochondrial matrix to the intermembrane space, creating a proton gradient across the inner mitochondrial membrane. The energy released when the protons flow back into the mitochondrial interior is used to form ATP (Figure 2) (1). In addition to its role in ATP synthesis, mitochondrial coenzyme Q10 mediates the oxidation of dihydroorotate to orotate in the de novo pyrimidine synthesis.

https://onlinelibrary.wiley.com/doi/abs/10.1002/hup.2687Title: The effect of memantine in adult patients with attention deficit hyperactivity disorder” The results of this study indicated that memantine was effective in reducing symptoms of Inattention/Memory Problems, Hyperactivity/Restlessness, Impulsivity/Emotional Lability”

https://www.webmd.com/alzheimers/guide/nmda-receptor-antagonists#1

Title: NMDA Receptor Antagonists and Alzheimer’s(memantine)

https://patents.google.com/patent/EP0911026A1/enTitle: Creatine derivatives for asthmaTherapeutic agents for asthma in the present invention means a drug used for so-called treatment performed in the hope of remitting the symptoms of asthma, and preventive treatment. It is known that creatine, a typical compound used in the present invention, is deeply involved with ATP (adenosine triphosphate) which is a kinetic energy. (See, e.g., Roger Hariss, Eric Hultman, Clinical Science (1993): 84, 565 – 5711.) However, no effect of such compounds as creatine for asthma has been known yet. The chemical formula of creatine is as shown in the chemical formula 2 below”” Seven asthmatics (average age; 40, 4 males and 3 females) took 4 g/day creatine orally, and all of showed improvement of pulmonary function and decreased in frequency of on-demand uses of β2-stimulant-inhalants”Thus, the drug of the present invention has an excellent inhibitory effect against the delayed-type asthmatic reaction in bronchial asthma. Also the drug of the present invention has no side effect and is safe for the human body”

https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-015-0390-6
Title: ATP regulation in bioproduction
The strategies used to enhance ATP supply are categorized as follows: addition of energy substrates, controlling pH, metabolic engineering of ATP-generating or ATP-consuming pathways, and controlling reactions of the respiratory chain.”

The addition of citric acid effectively increases the ATP supply. The elevated ATP supply improves the tolerance of Candida glabrata to extracellular pH values of 4.5–5.0 and enhances the yield of pyruvic acid [19]. Addition of citric acid as an auxiliary energy substrate for dehydrogenase reactions by malic enzyme that generate NADH enhances the contribution of electrons from NADH, which pass through the electron transfer chain to generate a proton-motive force that enhances respiratory ATP synthesis via membrane-localized FoF1-ATP synthase [19]. Citric acid addition increases the cytosolic pH and decreases the vacuolar pH. This result led to the proposal that the elevated ATP supply induced by citric acid addition enhances V-ATPase to transport H+ from the cytosol to the vacuole, which improves tolerance to acidic pH that is accompanied by an increase in cell growth that, in turn, increases the yield of pyruvic acid [19].

Moreover, enhancing the ATP supply by up-regulating the expression of genes encoding citrate lyase, malate dehydrogenase, and malic enzyme, which are components of the citric acid pathway (Fig. 3), by 10- to 120-fold caused by addition of citric acid is effective for producing pyruvic acid biosynthesis in Lactobacillus panis [20]. During the stationary phase of growth, enhanced pyruvic acid production increases the amount of acetic acid available to generate ATP through acetate kinase. Further, enhanced pyruvic acid production increases lactic acid biosynthesis through lactate dehydrogenase (Fig. 3) and lactic acid export through a citric acid-lactic acid exchanger [20] that reduces ATP consumption required to maintain the pH in L. panis [20]. Overall, the increase in the ATP supply due to enhanced ATP generation and reduced ATP consumption induced by the addition of citric acid increases cell growth and lactic acid production.

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